Montelukast is a leukotriene receptor antagonist used to treat the symptoms of asthma and COPD which include wheezing, shortness of breath, and chest tightness. Montelukast is available as a tablet, a chewable tablet, or granules. Montelukast may also be used to treat seasonal or year round allergies.
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Montelukast blocks the action of leukotrienes. Leukotrienes are fatty signaling molecules which the body produces when there is inflammation. They are thought to play a key role in causing the symptoms of asthma and hay fever. They contribute to the pathophysiology of asthma, causing inflammation and swelling in the airways, airflow obstruction, increased secretion of mucus, mucosal accumulation, and bronchoconstriction.
The most common side effects related to taking montelukast include: Cough, Diarrhea, Ear infection, Earache, Sinus infection, Sore throat, Stomach pain, Upper respiratory infection. Singulair can also cause these much rarer but potential serious side effects: mood changes, hostility, aggression, agitation, vivid and unpleasant dreams, confusion, anxiety, hallucinations, sleepwalking, suicidal thoughts, suicidal actions (including suicide), insomnia, tremor, and depression.
In a study carried out by Professor Nathan Rabinovitch, MD, two biomarkers were identified which could help doctors predict more accurately which patients will benefit the most from montelukast. Singulair helps some patients, but not others.
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